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doi:10.1124/mol.106.026344 pmid:16835357 Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, And S, Maggiolini M (2006b) The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells

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Some individuals also notice: more stable energy levels fewer blood sugar crashes reduced overeating better appetite regulation These changes may indirectly support healthier metabolism and long-term fat loss

Conversely, higher doses offer little benefitand may cause harmif you're already losing weight steadily, experiencing significant nausea or vomiting, or if your genetics suggest you respond well at standard doses

You may notice improved energy levels within two to four weeks, while skin improvements such as a clearer complexion and a more even glow generally take six to twelve weeks of consistent use